Consistency of Responses to Repeated DDAVP Infusions in Patients With

The consistency in time of responses to separate desmopressin (DDAVP) infusions in patients with von Willebrand’s disease (vWD) and mild or moderate hemophilia A has been the subject of limited investigation. We report here the results of a clinical study undertaken to test the consistency of responses to repeated DDAVP administrations in 22 patients with vWD and 1 0 with mild or moderate hemophilia A (time interval between first and last infusion ranging from 1 to 77 months; median, 13 months). In patients with vWD, 80% of cases showed a departure of less than 20% from the average VIll:C peak level calculated after the two infusions. A similarly consistent pattern was observed for bleeding times recorded 30 minutes after